Saturday, April 24, 2010
For all of my adulthood, I have also struggled with insulin Resistance. Too much insulin in my college years left me hypoglycemic. Frank Resistance during my pregnancies left me with gestational diabetes. And since the end of my child bearing years my Resistance has grown into Metabolic Syndrome and Pre-diabetes, with type 2 hovering dangerously close with A1c's hovering between 5.3 and 6.4.
My doctors rightly warn me that my increased weight is a factor in my insulin Resistance even though the Resistance started well before I was of a weight that could not be considered anorexic. The best way to treat Metabolic Syndrome and Pre-diabetes is with diet and exercise. And especially in the past year, I can honestly claim that I exercise more and eat a better diet than most people. But still my weight is a constant issue. I will lose for a while and then inexplicably start to gain again.
I was hoping that the new diagnosis of severe sleep apnea and proper treatment would help me improve my metabolism as lack of sleep has metabolic consequences. Now I read in this article that the problem may be more genetic than even I was giving it credit for.
"He's shown that expression in the liver
of the enzyme PKC-delta determined whether animals were susceptible to insulin resistance and, subsequently, factors of metabolic syndrome.
Depending on the levels of this enzyme, some mice can eat more and be less active, but still won't become insulin resistant, thus maintaing a healthy weight. Mice with the opposite genetic profile eat less, move around a lot more, but can't tolerate glucose and thus become obese."
I guess the take away for me is that I can't tolerate the sugar, so give it up.
"Even after accounting for factors such as age at first menstrual period, adult body mass index, and breast density, a large body size at age seven was linked with a 27% reduction in risk of postmenopausal breast cancer. The protective effect of a larger body size at age seven was observed regardless of estrogen-receptor and progesterone-receptor status but was stronger for estrogen receptor-negative cancers than for estrogen receptor-positive cancers."
Apparently having been underweight as a child contributed to my breast cancer risk. Still, I expect that the world, in their fat phobic frenzy will quote "Obesity is a risk factor in many cancers, including breast cancer." We'll yes, in post menopausal women with estrogen sensitive cancer.
"In the case of breast cancer, higher body weight reduces the risk of breast cancer in premenopausal women but increases the risk in postmenopausal women."
In women like me, my increased pre-menopausal girth should have been a protective factor, not an increased risk factor. And also, because my cancer wasn't hormone sensitive, my weight shouldn't be a risk factor now that chemotherapy and age has left me on the other side of the pause. If I get a recurrance, or a second primary breast cancer it is overwhelmingly likely to be er/pr-, Her2/neu strongly positive. It seems the real risk was my anorexic state when I was seven years old.
The take away for me is that the medical field and the health and wellness industry need to stop generalizing and classify these risks as they really occur. And they need to let those little girls eat if they are hungry...just not McDonalds. Try some whole grains, lean meats and fruits and vegetables.
Thursday, April 22, 2010
Monday, April 19, 2010
Wednesday, April 14, 2010
Monday, April 5, 2010
Sunday, April 4, 2010
Saturday, April 3, 2010
I went to see my cardiologist last week and sleep specialist that is in Dr. K's office. I'm getting a sleep study done tomorrow night. Kind of afraid that I'm going to spend a bunch of money for something that isn't going anywhere. We'll see. Dr. K isn't the first doctor to tell me that I need to see a sleep specialist, he's just the first to have the doctor in his office and arrange for me to see one. So weird night sleep with everything being monitored it is. It's just Dr. L, the sleep specialist put on the orders "First available appointment" and then I was given one for the same week. It's kind of reminiscent of the breast cancer diagnosis. I've gotten to where I don't like the front of the line. At least this time I doubt they are going to tell me that I'm going to die of snoring.
Well, I guess I should go buy some eggs and dye and potatoes and stuff.